Company BUSINESS
R&D PROJECTS
CMRI, specialized in probiotics,
has accumulated Research Data for more than 30 years.
We are focusing on developing better probiotics by solving problems through continuous R&D projects
-
1. BACILLUS COAGULANS (Spore-based probiotics)Individually recognized ingredient (Application no. 2023-034)
Manufacturer and seller's biggest concernIs poor thermal stability and low intestinal survival rates.
Lack of heat stability is a problem, as it limits available formulation options (stick packaging or capsule), and causes problems with setting an expiration date.
If the intestinal survival rate is low, repurchase rate of the product will decrease due to lack of effectiveness, which inevitably increases costs due to having to select designs that contain more ingredients.Qualities of Bacillus coagulansSurrounded by a natural double protective film, B.coagulans is resistant to heat and pressure generated during manufacturing.
B.coagulans, which has a high intestinal survival rate and excellent efficacy, rapidly increases as spores are activated and germinated in the intestinal environment, in this way producing large amounts of L-form lactic acid.
'Lactic acid-producing Bacillus', scientifically called B.coagulans, forms spores on its own, resulting in the ability to protect itself from the outside.
Specifications of B.coagulansDerived from Green Malt Scientific name Bacillus coagulans SNZ 1969 Manufacturer Sanzyme (India) Functional
ingredientAmount of probiotics (B.coagulans, more than 1B CFU/g) Daily intake Bacillus coagulans SNZ 1969 1B CFU/day in probiotics (10mg based on raw ingredients) Functionality Can help facilitate bowel movement 
-
2. Entelac® intestinal coated probiotics (Beads patent)Coating beads
A coating layer that protects probiotics from acid or humidity, in this way increasing the survival rate in the stomach, allowing for the formulation to easily dissolve in the intestines
Beads Development
01(B.coagulans SNZ1969 + general probiotics)
probiotic bead researchB.coagulans SNZ1969General probiotics + prebiotics
02Vitamin and mineral bead research
Vitamin & mineral beadsResearch on bitter-taste masking
(red ginseng, Korean ginseng etc.)Dietary fiber bead formulationResearch on beads containing fat-soluble substancesResearch on enzyme beads (PrebioZyme)Capsule Filling Device Patent (New Formulations)
ctcbio’s Patented New Formulations – CinC®, TinC®, BinC®
Solve stability problems by using new Capsule in Capsule formulation
New formulation with ctcbio’s
innovative technologySecuring Korean/international
patents through development
of new formulations
Ensuring stability by
suppressing interactionPossible to develop probiotic
complex of ingredients which
show interference in stability
Specialized in the development
of formulations for food
and pharmaceuticalsProduct development of various
applications through professional
formulation development
01First in Korea
02Tablet in Capsule –
formulation exclusive
to ctcbio
03Completed Korean
patent application
04Proprietary manufacturing
and sales of capsule fillers -
3. Prebiozyme (혈당 강하 효소 복합제)
일반적으로 섭취된 음식물 중 탄수화물은 이당류(엿당, 젖당, 설탕)를 거쳐 소장에서 여러 효소 작용으로 단당류(포도당, 갈락토오스, 과당)로 분해되어 흡수됩니다.
혈당 강하 효소 복합제는 이렇게 분해된 포도당을 인체에 흡수되지 않는 형태의 당으로 전환함으로써 인체에 흡수되는 포도당의 양을 조절할 수 있습니다.
비만으로 인해 탄수화물 섭취를 조절해야 하는 사람 또는 고혈당증이나 당뇨병으로 인해 혈당 조절이 필요한 사람에게 유용할 것으로 기대합니다. -
3. Development of other new materials (ginseng leaves)
Ginseng leaf hydrolysate_ Compound for improving skin wrinklesWe have developed a method of producing ginseng residue by adding an acid solution to a ginseng extract. With this residue as active ingredient, we developed a cosmetic compound that prevents and improves skin wrinkles.
MeritsSince the active ingredient of the acid solution has excellent collagenase-stimulating properties, it can be used in the cosmetic industry for preventing or improving skin wrinkles.
-
4. Diagnostic systems
A. Telomere length analysis
(body age measurement)Research on methods and compounds for increasing intracellular telomerase activity.
Useful for treating diseases treated by increasing telomerase activity in cells or tissues of patients, such as HIV infection, various degenerative diseases, and acute or chronic skin diseases, and for improving cell replication capacity and stem cell proliferation during cultivation, such as in vitro cell therapy.
B. Microbiome analysis (intestinal flora)Intestinal microbes are invisible to our eyes, but they are called the "third organ of the human body" and perform diverse and important functions. Not only do they help us absorb the nutrients we consume efficiently, but they also produce nutrients that the human body cannot make, and prevent pathogenic microorganisms such as viruses and bacteria from entering our body.
Intestinal microbes have been found to have a variety of functions, affecting the body's metabolism, nutrition, immune system, and nerves, and they are also associated with atopic dermatitis, obesity, diabetes and even psychological disorders such as depression. By checking the balance of intestinal microorganisms through microbiome analysis, and adjusting lifestyle and eating habits accordingly, it is possible to create a balanced and strong intestinal environment.